2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-141171
    TCO-PEG24-NHS ester 2055646-26-7
    TCO-PEG24-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. TCO-PEG24-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
    TCO-PEG24-NHS ester
  • HY-133330
    Amino-PEG27-amine 2252208-09-4
    Amino-PEG27-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG27-amine
  • HY-140095
    N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester) 2112732-01-9
    N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester)
  • HY-141071
    N-(m-PEG4)-N'-(DBCO-PEG4)-Cy5 2107273-76-5
    N-(m-PEG4)-N'-(DBCO-PEG4)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(m-PEG4)-N'-(DBCO-PEG4)-Cy5 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    N-(m-PEG4)-N'-(DBCO-PEG4)-Cy5
  • HY-140402
    Aminooxy-PEG4-C2-Boc 2100306-82-7
    Aminooxy-PEG4-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Aminooxy-PEG4-C2-Boc
  • HY-140083
    Propargyl-PEG2-N-bis(PEG2) 2100306-62-3
    Propargyl-PEG2-N-bis(PEG2) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG2-N-bis(PEG2) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG2-N-bis(PEG2)
  • HY-140656B
    Biotin-PEG2000-Biotin
    Biotin-PEG2000-Biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG2000-Biotin
  • HY-138378
    Benzyl-PEG5-NHBoc 2064292-55-1
    Benzyl-PEG5-NHBoc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG5-NHBoc
  • HY-135943
    NH2-PEG8-C1-Boc
    NH2-PEG8-C1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH2-PEG8-C1-Boc
  • HY-147206D
    Biotin-PEG5000-Alk
    Biotin-PEG5000-Alk is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Biotin-PEG5000-Alk is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Biotin-PEG5000-Alk
  • HY-130738
    Benzyl-PEG3-CH2-Boc 1443467-88-6
    Benzyl-PEG3-CH2-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Benzyl-PEG3-CH2-Boc
  • HY-130172
    Benzyl-PEG2-CH2-Boc 1643957-26-9 98.0%
    Benzyl-PEG2-CH2-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Benzyl-PEG2-CH2-Boc
  • HY-140137
    WSPC Biotin-PEG3-DBCO
    WSPC Biotin-PEG3-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. WSPC Biotin-PEG3-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    WSPC Biotin-PEG3-DBCO
  • HY-138763
    Propargyl-PEG11-acid
    Propargyl-PEG11-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG11-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG11-acid
  • HY-138307
    NH2-PEG10000-Strt
    NH2-PEG10000-Strt is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    NH2-PEG10000-Strt
  • HY-141328
    Thiol-PEG4-Boc 564476-33-1
    Thiol-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Thiol-PEG4-Boc
  • HY-140837
    Boc-NH-PEG5-azide 911209-07-9
    Boc-NH-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-NH-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Boc-NH-PEG5-azide
  • HY-140542
    N-Benzyl-N-bis(PEG3-acid) 2093154-03-9
    N-Benzyl-N-bis(PEG3-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-Benzyl-N-bis(PEG3-acid)
  • HY-141262
    Methyltetrazine-PEG24-amine 2353410-18-9
    Methyltetrazine-PEG24-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Methyltetrazine-PEG24-amine
  • HY-140268
    DBCO-PEG8-acid 2765066-35-9
    DBCO-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG8-acid is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG8-acid
PROTAC Linkers Isoform Comparison

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